内质网应激及其在骨肉瘤中作用的研究进展
任杰
魏巍
154000 黑龙江省,佳木斯大学附属第一医院骨外二科
摘要：Endoplasmic reticulum(ER)is a key organelle for cell function and metabolic adaptation.Disrupted ER homeostasis,including hypoxia,insufficient amino acid supply and lactic acidosis,will lead to ER stress(ERS),further unfolded protein response(UPR),ER associated protein degradation(ERAD),activation of autophagy pathway and other abnormal reactions,resulting in metabolic disorders of some important proteins in the body.It has been confirmed that ERS is involved in the pathogenesis of diabetes,breast cancer,lung cancer,prostate cancer and other diseases.Reganding the role of ERS in osteosarcoma,there are some latest research results at home and abroad.In this paper,we reviewed the mechanisms of endoplasmic reticulum stress and related signaling pathways targeting Ca2+,reactive oxygen species(ROS),epithelial mesenchymal transformation(EMT),ncRNA,etc.,in order to provide new ideas for future research and treatment strategies of osteosarcoma.
关键词：骨肉瘤内质网应激信号通路综述
分类号：R738.1(运动系肿瘤)
资助基金：黑龙江省卫生计生委科研课题(2018300)
论文发表日期：2024-08-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 667-672 )
英文信息