骨肉瘤免疫微环境机制及免疫治疗的研究进展
郭超凡
李利军
030012 太原,山西省人民医院(山西医科大学第五临床医学院)骨科
摘要：Osteosarcoma is a rare but deadly group of malignant tumors,including multiple subtypes and complex biological characteristics.The role of immune microenvironment of these tumors is gradually receiving attention and is considered as a key factor affecting treatment response and prognosis.This review paper aims to delve into the mechanisms of the immune microenvironment in osteosarcoma and the research progress of immunotherapy in this field.We first summarized the basic biology of the immune microenvironment of osteosarcoma,especially the role of T cells,macrophages,and other immune cells in the tumor microenvironment.Next,we reviewed the current immunotherapy strategies,including immune checkpoint inhibitors and immune cell therapy,as well as their applications and limitations in osteosarcoma.Although the immune microenvironment of osteosarcoma is complex and challenging,understanding its underlying mechanisms is expected to provide theoretical basis for developing more effective immunotherapy.
关键词：骨肉瘤免疫疗法肿瘤微环境抗肿瘤药免疫综述
分类号：R738.1(运动系肿瘤)
资助基金：山西省科技创新人才团队(202204051002035)
论文发表日期：2024-08-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 662-666 )
英文信息