应激颗粒及其相关蛋白TDP-43在骨关节炎中的研究进展
刘岸龙1
史冬泉2
赵建宁1
1.210022 江苏省,南京市中医院骨伤科2.210008 江苏省,南京鼓楼医院运动医学与成人重建外科
摘要：Osteoarthritis(OA)is an irreversible degenerative disease with high morbidity and disability.Considering the current situation of 360 million OA patients in the world and more than 100 million OA patients in China,it is an urgent problem to solve.Mechanical stress,oxidative stress and aging are all involved in the pathological process of OA.Previous studies could not fully explain this process by considering OA from a single perspective.Stress granules can form in the cytoplasm after cells are subjected to mechanical stress,oxidative stress or senescence,and regulate the function and state of cells.There are few studies on the regulation of OA progression by stress granules.However,TDP-43,one of the formation proteins of stress granules,is found to be closely related to degenerative diseases in the elderly and plays a key role in OA progression.This paper reviews the role and mechanism of TDP-43 protein in OA.
关键词：骨关节炎应激颗粒TDP-43综述
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
资助基金：中国博士后科学基金(2020M671452)
论文发表日期：2024-06-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 476-480 )
英文信息