细胞片技术在肌腱再生组织工程学中的应用进展
谌业帅
史冬泉
徐兴全
蒋青
1.南京医科大学鼓楼临床医学院关节疾病诊治中心, 江苏,2100082.南京医科大学鼓楼临床医学院关节疾病诊治中心, 江苏,2100083.南京医科大学鼓楼临床医学院关节疾病诊治中心, 江苏,2100084.南京医科大学鼓楼临床医学院关节疾病诊治中心, 江苏,210008
摘要：Tendon injuries are common diseases which could induce substantial pain and loss of functions. Current clinical therapy of tendon injury has some disadvantages, such like the limitation of the graft which have fueled the search for tissue-engineered substitutes. Many achievements have been made during past several years. Many kinds of cells nowadays have been used in an attempt to enhance the healing of tendons: ifbroblast cell lines, mesenchymal stem cells ( MSCs ), embryonic stem cells ( ESCs ) and induced pluripotent stem cells ( iPSCs ). And a large number of scaffold materials also have been explored for tendon tissue engineering including natural substances ( silk, collagen ) and synthetic biodegradable materials ( poly lactic-co-glycolic acid ). Beside gene-related approaches, the approach of tendon tissue engineering also involve some physical methods like mechanical stimulation. However, the traditional tissue engineering with scaffolds has some disadvantages. Naturally derived polymers generally show good biocompatibility but low ductility whereas the synthetic polymers exhibit a high tunability but may cause negative immune response from the body, and the scaffolds can’t fully simulate the environment between cells. To avoid this, cell sheet engineering has been developed as a unique, scaffold-free method of cell processing. In this review, some methods for making cell sheet and its application in tendon tissue engineering are described.
关键词：腱损伤创伤和损伤组织工程综述
分类号：R686(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81125013)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 809-812 )
英文信息