他汀类药物抗骨质疏松作用的实验研究进展
项力源1
田发明2
刘会仁1
胡克俭1
刘家寅2
1.唐山市第二医院, 河北,0630002.河北联合大学
摘要：Statins are 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitors,which inhibit the endogenous synthesis of cholesterol.Recent studies have shown that statins can promote the proliferation of osteoblasts and bone formation and increase the mRNA level in bone morphogenetic protein 2 ( BMP2 ) in vitro.The literatures relevant to the experimental research on statins for the prevention and treatment of osteoporosis are summarized and analyzed in the paper,and the mechanism of anti-osteoporosis and application prospects of statins are brielfy reviewed.
关键词：骨质疏松药物疗法药物载体剂量效应关系药物
分类号：R681(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 419-422 )
英文信息