水通道蛋白的表达与关节炎关系的研究进展
冯芳芳1
于超1
谭春江2
陈文列3
陈赛楠1
1.福建中医药大学, 福州,3501222.福建中西医结合研究院; 福建省中西医结合老年性 疾病重点实验室3.福建中西医结合研究院; 国家中医药三级科研实验室-中药药理 细胞结构与功能 实验室
摘要：Aquaporins ( AQPs ) act as an important channel for body water crossing the cell membrane, and are closely related to the balance of water metabolism and water reserves. Recent studies have found that there are signiifcant differences in the expressions of AQPs in arthritis joints and normal joints. The expressions of AQP1, AQP3 and AQP9 in the patients with rheumatoid arthritis and osteoarthritis are all signiifcantly increased, which are enhanced with the occurrence of lesions. The expressions of AQP4 are higher in the patients with gouty arthritis and osteoarthritis than in the patients with normal joints, which can reflect the severity of articular diseases. After medication, the expressions of AQPs are remarkably reduced, and the arthritis symptoms are improved. It points out that a special intimate relationship exists between the upregulation of the expressions of AQPs in arthritis joints and the occurrence and development of pathological changes. With AQPs as therapeutic targets, the cell membrane permeability to water can be reduced through regulation, so as to improve inlfammation. It offers a new research idea for the prevention and control of arthritis. In this paper, the studies on the relationship between AQPs and arthritis in recent years are reviewed.
关键词：水通道蛋白质 1水通道蛋白质 3水通道蛋白质 4水通道蛋白质 9骨关节炎关节炎类风湿性
资助基金：福建省自然科学基金(2014J01356)福建省科技重大项目(2012Y4006)国家自然科学基金(81202836)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 323-327 )
英文信息