微基因修饰雪旺氏细胞移植对脊髓损伤中枢传导功能的作用
陈礼刚1
高立达1
周虎田1
曾凡俊1
毛伯镛2
李讯2
卢敏2
1.Chengdu General Hospital of Chengdu Military Command2.lst Affiliated Hospital of West China University of Medical Science
摘要：Objective To approach the effect of microgene pSVPoMcat to modify genetically Schwann cells (SC) on central conduction functionafter spinal cord injury (SCI) . Method Experimental animals were divided into three groups: the group of microgene pSVPoMcat implanted to genetically modify SC (group A), SC implanted group (group B), and the control group (group C). The cortical somatasensory evoked potentials (CESP) and combined behavioral score (CBS) were continuous monitored from operation second week to twelfth week Result The result showed that the peak latency and peak amplitudes of group A, B have a recovery tendency and it was constant with CBS. Conclusion We concluded that the microgene pSVPoMcat to modify genetically Sc may play a promotion role in recovery of central conduction function after SCI.
机标关键词：雪旺氏细胞移植脊髓损伤基因修饰微基因传导功能
分类号：R74(神经病学与精神病学)
论文发表日期：2001-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 151，153 )
英文信息