乳酸对心肌收缩力和细胞动作电位的影响与运动能力的相关性
LIU Zhao-qiang
LIU Ying-jie
ZHU Ji-tian
SHI Qing-zhao
摘要：Objective To study the effect of lactate of differentconcentration on the action potential of ventricular papillary muscle cell (n=4) and contractile force (n=10).Method Using intracellular microelectrode technique and microtension depicting method.Result The Result showed the effect of lactated solution of a certain comcentration became obvious. After perfused with lactate solution of 4mmol/L,the vilocity maximum decreased significantly (p<0.05) showed the 4mmol/L lactate solution decreased the rate of depolarization: decreased the efficency of Na + channel; lactate solution decreased the contractile force of cardiac muscle. Conclusion The possible mechanism was: Ca+ influx and Na+ - H+ exchange were inhibited, resulted in the elevation of intracellular H+ concentration; through Na+-Ca2+ exchange, Ca2+ efflux decreased resulted in the intracellular Ca2+ decreased resulted in the intracellular Ca2+ overload.
机标关键词：乳酸心肌收缩力细胞动作电位运动能力相关性Action Potentialpapillary muscleaction potential
分类号：R49(康复医学)
论文发表日期：2001-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 155-156 )
英文信息