Research progress in gelatin-based composite hydrogel
LIU Ruixue
ZHOU Teng
FAN Xiaomin
LI Yunqiu
FENG Haoze
Abstract：The research status of the improvement of the mechanical properties and the functionalization of gelatin-based hydrogels from the cross-linking modification of gelatin, blending with other polymers( including interpenetrating network and dual network), and recombination with nanomaterials was reviewed. It was pointed out that the chemical cross-linking modification of gelatin was more widely used than physical cross-linking modification, but the excessive amount of chemical cross-linking agent would produce certain toxicity; the interpenetrating network could combine gelatin with other polymer networks. The nature of the dual network topology could greatly improve the mechanical properties of gelatin-based composite hydrogels; the introduction of different nanoparticles or nanoparticles with special functions into the gelatin system could avoid the toxicity of traditional chemical crosslinkers. Functionalized gelatin based nanocomposite hydrogel with high tensile strength was obtained. Further optimization and design of gelatin-based hydrogel materials with mechanical strength, biocompatibility and tissue adhesion suitable for biological tissues to improve their mechanical properties and stimuli in complex environments will be the future research direction.
Keywords：gelation-based composite hydrogelcross-linking modificationinterpenetrating networkdouble networknanocomposite
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：14( 42-54,81 )