Research progress of the major HAAs
FU Yufeng
HU Shaodong
DUAN Kun
WANG Baolin
SUN Zhitao
LU Changtong
TIAN Haiying
HAO Hui
Abstract：The classification and hazard of HAAs,the detection of heterocyclic aromatic amines (HAAs)in cigarette smoke,the metabolism research progress of main HAAs and monitoring methods of human exposure were reviewed.It was pointed out that HAAs were highly carcinogenic and mutagenic.There are ten main HAAs in cigarette smoke,and the higher contents are Harman,Norharman,AαC and MeAαC.Studies of major heterocyclic amines in cigarette smoke are mostly focused on AαC and MeAαC.The metabolic pathways of AαC and MeAαC have been clarified,but there is a slight difference in the literature regarding the amount of their metabolites.The exposure monitoring of HAAs is mainly achieved through the detection of prototype HAAs in human urine or hair,metabolites of HAAs can be used as exposure markers for monitoring the exposure of HAAs.Future research will focus on the synergistic mutagenesis of Harman and Norharman,metabolites of AαC and MeAαC as exposure markers,rapid and effective detection method to determine HAAs in biological sample and the correlation between smoking and the exposure of HAAs to further reduce the harmfulness of HAAs and provide references for the study of "smoking and health".
Keywords：heterocyclic aromatic aminesmetabolitesexposure level monitoring
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：13( 13-25 )