The preliminary research on the antibacterial PLGA membrane
WANG Meng-lu
PAN Wen-wen
Abstract：Taking the thin film of PLGA without carboxyl end group as the material,sodium hydroxide and ultraviolet ray were adopted respectively to make it with carboxyl end group.Atomic force microscopy was used to characterized the thin film of PLGA after treatment,and its hydrophily was tested.Then grafting the active protein bacitracin through the carbodiimide sequential method,and the antibacterial performance of the thin film of PLGA before and after grafted was tested respectively by the methods of acridine orange fluorescence staining and MTT method.The results showed that the chemical structure of the thin film of PLGA dealt with sodium hydroxide and ultraviolet ray changed obviously.Compared with the blank thin film,the hydrophily of the thin film of PLGA after treatment became bigger.Compared with the thin film of PLGA without grafting,the thin film of PLGA after grating had the certain antibacterial performance,and the antibacterial performance gradually decreased as the grating concentration increased.
Keywords：PLGA filmBacitracingraftantibacterial performance
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 38-42 )