Preparation and photothermal antimicrobial properties of dual antimicrobial peptide-functionalized copper sulfide nanocomposites
LIU Zhimin
ZHANG Mingwei
MEI Lin
Abstract：Copper sulfide nanoparticles exhibit good photothermal conversion properties under near-infrared light irradiation.However,their limited direct binding capability with bacteria restricts their photothermal antibacterial efficiency.A novel composite nanomaterial was constructed by co-immobilizing polymyxin B and bacitracin onto the surface of copper sulfide nanoparticles via an in-situ modification method.The prepared composite nanomaterial was characterized using ultraviolet-visible spectroscopy,infrared spectroscopy and transmission electron microscopy.The antibacterial nanocomposite has good photothermal conversion performance and recyclability under near-infrared light irradiation.In addition,antibacterial experiments showed that the nanocomposite could effectively inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa under 808 nm light irradiation.This new type of antibacterial material combines the innate antibacterial properties of antimicrobial peptides and the photothermal antibacterial characteristics of copper sulfide,which has a high antibacterial activity against both Gram-negative and Gram-positive bacteria.Therefore,the material has potential application value in the biomedical field.
Keywords：photothermal propertiesantibacterial propertiescopper sulfide nanoparticlesantimicrobial peptides
Publication Date：2025-12-25
Online Publishing Date：2026-01-27(First online date of this platform, not the publication date of the document)
Pages：6( 55-60 )