The Effect of Combined Acupuncture and Medication Intervention on Circadian Rhythm of Blood Pressure in Patients with Non-dipper Hypertension
ZHOU Haoling
REN Fei
SHI Hongwei
LAI Sihua
ZHANG Cong
CHEN Li
Abstract：Objective:To observe the effect of acupuncture at Neiguan(PC6)-Jueyinshu(BL14)combined with oral western medicine on the circadian rhythm of blood pressure in patients with non-dipper hypertension.Methods:Sixty patients with non-dipper hypertension were randomly divided into the control group and the treatment group,with 30 cases in each group.The control group was received conventional treatment(health education combined with oral western medicine),while the treatment group was received additional acupuncture treatment on the basis of the control group.The selected acupoints were Neiguan(PC6,bilateral),Jueyinshu(BL14,bilateral),Taichong(LR3,bilateral),and Baihui(GV20).Two groups were treated for 8 weeks.Results:The total effective rate of circadian rhythm improvement of blood pressure in the treatment group was 80.00％,which was significantly higher than 36.67％in the control group,and the difference was statistically significant(P<0.001).After treatment,the nocturnal blood pressure reduction rate in the treatment group was significantly higher than that before treatment(P<0.05),and also higher than that in the control group after treatment(P<0.05).After treatment,the 24 h mean systolic blood pressure(24 h-MSBP),daytime mean systolic blood pressure(d-MSBP),and nighttime mean systolic blood pressure(n-MSBP)in both groups were significantly lower than those before treatment(P<0.05),the n-MSBP in the treatment group after treatment was lower than that in the control group(P<0.05).After treatment,the 24 h mean diastolic blood pressure(24 h-MDBP),daytime mean diastolic blood pressure(d-MDBP),and nighttime mean diastolic blood pressure(n-MDBP)in both groups were significantly lower than those before treatment(P<0.05),while the d-MDBP in the treatment group after treatment was slightly higher than that in the control group(P<0.05).The score of the Du's Hypertension Quality of Life Scale in the treatment group after treatment was higher than that before treatment(P<0.05),the score in the treatment group was higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Acupuncture at Neiguan(PC6)-Jueyinshu(BL14)combined with oral western medicine had a good regulatory effect on the circadian rhythm of blood pressure in patients with non-dipper hypertension,and its effect was superior to that of oral western medicine alone.Both acupuncture at Neiguan(PC6)-Jueyinshu(BL14)combined with oral western medicine and oral western medicine alone had a certain hypotensive effect on patients with non-dipper hypertension.In terms of nocturnal mean systolic blood pressure,the hypotensive effect of combined acupuncture and medication was better than that of oral western medicine alone.In addition,acupuncture at Neiguan(PC6)-Jueyinshu(BL14)combined with oral western medicine could effectively improve the clinical accompanying symptoms and quality of life in patients with non-dipper hypertension.
Keywords：non-dipper hypertensioncircadian rhythm of blood pressurecombination of acupuncture and medicationacupuncture
Publication Date：2026-03-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：6( 843-848 )