The Mechanism of Shengui Decoction for Treatment of Arrhythmia in Rats with Acute Myocardial Ischemia Model
WANG Fengru
LI Fengxia
LI Bingfei
WU Chen
LI Guojian
ZHOU Linlin
ZHENG Yadu
XU Jingyu
Abstract：Objective:To investigate the protective effect of Shengui Decoction on arrhythmia in rats with acute myocardial ischemia model.Methods:Eighty-four SD rats were randomly divided into the blank control group(NC group),the sham operation group(Sham group),the model group(MI group),the amiodarone group(PC group),the Shengui Decoction high dose group(SHD group),the Shengui Decoction medium dose group(SMD group),and Shengui Decoction low dose group(SLD group).The corresponding dose of the drug was gavaged for 14 days.After ligating the left coronary artery,changes in the standard Ⅱ lead electrocardiogram and J-point voltage were recorded of the rats in each group at 0 minutes(pre-ligation)and at 10,30,60,and 360 minutes post-ligation.The left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),heart rate(HR),maximum rate of increase in left ventricular pressure(+dp/dtmax),and maximum rate of decrease in left ventricular pressure(-dp/dtmax)were detected through Hemodynamics.Results:All dosage groups of Shengui Decoction and the PC group the elevation of the J-point at 10,30,60,and 360 minutes post-ligation effectively were reduced,and the J-point elevation significantly lower than that in the MI group(P＜0.01).Compared with the MI group,the SHD group exhibited a more pronounced reduction in J-point elevation at 360 min post-ligation(P＜0.01).The SMD group showed a less significant reduction in J-point elevation compared with that in the PC group at 360 min post-ligation(P＜0.05),while the difference at 10 min post-ligation was not statistically significant with the PC group(P＞0.05).At all time points post-ligation,the reduction in J-point elevation in the SLD group was less pronounced than that in the PC group(P＜0.05).The results of Hemodynamic showed that compared with the MI group,LVEDP significantly in all dosage groups of Shengui Decoction decreaed(P＜0.05 or P＜0.01),while LVSP,+dp/dtmax,-dp/dtmax,and heart rate increasd(P＜0.05 or P＜0.01).Conclusion:All dosage groups of Shengui Decoction reduced the voltage elevation at the J-point in rats with coronary artery ligation,with stable state.Hemodynamic showed that Shengui Decoction could significantly decrease LVEDP,while significantly increased LVSP,+dp/dtmax,-dp/dtmax,and heart rate.The high-dose Shengui Decoction and amiodarone showed better effects.
Keywords：acute myocardial ischemiaarrhythmiaShengui Decoctionamiodaroneelectrocardiogramexperimental study
Publication Date：2026-02-10
Online Publishing Date：2026-03-09(First online date of this platform, not the publication date of the document)
Pages：8( 357-364 )