The Efficacy and Safety of Different Traditional Chinese Medicine Injections Combined with Conventinal Western Medicine for Treatment of Gestational Hypertension:a Network Meta-analysis
SONG Jiayuan
SHEN Weiping
MA Chun
LI Shuling
QIAN Taoming
YANG Lihua
Abstract：Objective:To evaluate the efficacy and safety of different traditional Chinese medicine injections combined with conventional Western medicine for treatment of gestational hypertension by the network Meta-analysis.Methods:The randomized controlled trials with traditional Chinese medicine injections and conventional Western medicines for treatment of gestational hypertension were searched from PubMed,Cochrane Library,SinoMed,Web of Science,EMbase,China National Knowledge Infrastructure(CNKI),Chinese Biomedical Literature Database,VIP and WanFang data from January 1,2000 to December 31,2023.All researchers independently conducted literature screening,data extraction,and quality assessment.The literatures that met the quality standards were analyzed with Stata 14.0 software,and quality evaluation was performed with ROB2.Results:A total of 38 literatures were included,involving 9 intervention measures,and a total of 3 857 subjects were involved.On the basis of conventional Western medicine,the combination of Mailuoning Injection showed the most significant effect in improving clinical efficacy and reducing the incidence of neonatal asphyxia,Chuanxiongqin Injection was most effective in improving systolic blood pressure,Danshen Chuanxiongqin Injection was most effective in improving diastolic blood pressure,Huangqi Injection was most effective in improving mean arterial pressure and urinary protein,Shenmai Injection was most effective in reducing the incidence of postpartum hemorrhage.Conclusion:The current evidence showed that all 9 types of traditional Chinese medicine injections could improve therapeutic effects,systolic blood pressure,diastolic blood pressure,mean arterial pressure,urine protein and other outcome indicators.Due to limitations in the quality of included literatures,these findings required further validation through multi-center,large-sample,double-blind randomized controlled trials.
Keywords：gestational hypertensiontraditional Chinese medicine injectioneffectsafetynetwork Meta-analysis
Publication Date：2026-02-10
Online Publishing Date：2026-03-09(First online date of this platform, not the publication date of the document)
Pages：12( 321-332 )