Progress in the Study of Comorbid Mechanism of Pain and Depression
ZHAI Jingrong
GUO Yan
Abstract：This paper reviews the research progress on the comorbidity mechanism of pain and depression, aiming to provide a reference for a deeper understanding of their mutual relationship and for more effective and comprehensive clinical treatment. Pain is a common symptom of many clinical diseases and seriously affects patients' quality of life. There is a mutual promoting effect between pain and depression. In clinical practice, some patients, as their pain worsens, may develop from initial anxiety to depression. At the same time, patients with depression often experience more severe pain than their actual condition. In recent years, a large body of evidence has shown that the pathogenic mechanisms of pain and depression are closely related.
Keywords：paindepressioncomorbid mechanismreview
Publication Date：2025-12-10
Online Publishing Date：2025-12-19(First online date of this platform, not the publication date of the document)
Pages：6( 3614-3619 )