The Mechanism of Panax Notoginseng in Intervening with Atherosclerosis Induced by Hyperlipidemia in Rabbits
YU Xuanxuan
GUO Ruiyou
Abstract：Objective:To observe the mechanism of Panax Notoginseng powder in intervening with the atherosclerosis of rabbits fed with hyperlipidemia diet.Methods:Twenty New Zealand white rabbits of the Sprague-Dawley strain were selected and fed with high-fat diet to establish the atherosclerosis model.The rabbits were randomly classified into the control group,the model group,the high-dose Panax Notoginseng group,and the low-dose Panax Notoginseng group,with 5 rabbits in each group.After administration for 10 weeks,serum total cholesterol(TC),triglycerides(TG)and low-density lipoprotein cholesterol(LDL-C)were tested.The degree of aortic AS plaque lesions was observed by hematoxylin-eosin(HE)staining.The ratio of lipid plaques area formed in the arterial vessels of the aorta to the total area of the arterial lumen(ratio of lipid plaque area)was observed by image analysis methods.The number of matrix metalloproteinase 2(MMP-2)and nuclear transcription factor-κB(NF-κB)positive cells in each 0.01 mm2 area was measured by immunohistochemical staining.Results:Compared with the control group,the levels of serum TC,TG,and LDL-C in the model group increased(P＜0.05).Compared with the model group,the levels of serum TC,TG,and LDL-C in the high-dose Panax Notoginseng group and the low-dose Panax Notoginseng group decreased(P＜0.05).Compared with the control group,the expression of MMP-2 and NF-κB positive cells in the model group increased(P＜0.01).Compared with the model group,the expressions of MMP-2 and NF-κB positive cells in the high-dose Panax Notoginseng group and the low-dose Panax Notoginseng group decreased(P＜0.01).Compared with the control group,arterial intima area,and the ratios of lipid plaque area in the model group enlarged(P＜0.05).Compared with the model group,arterial intima area,and the ratio of lipid plaque area in the high-dose Panax Notoginseng group and the low-dose Panax Notoginseng group reduced(P＜0.05).Conclusion:Panax Notoginseng powder might inhibit the formation of atherosclerosis by decreasing blood lipids,antioxidation,and inhibiting the expression of MMP-2 and NF-κB.
Keywords：atherosclerosisPanax Notoginsengmatrix metalloproteinase 2nuclear transcription factor-κBrabbitsexperimental study
Publication Date：2025-11-25
Online Publishing Date：2025-12-05(First online date of this platform, not the publication date of the document)
Pages：4( 3428-3431 )