Causal Relationship between Immune Cells and Dilated Cardiomyopathy Based on Mendelian Randomization Analysis
SUN Ruixue
ZHOU Qiang
WANG Shasha
GUO Changying
Abstract：Objective: To explore the causal relationship between immune cells and the risk of dilated cardiomyopathy using Mendelian randomization. Methods: Based on publicly available genetic data, we used a two-way Mendelian randomization approach to investigate the causal relationship between 731 immune cell traits and the risk of dilated cardiomyopathy. We performed Mendelian randomization analysis using inverse variance weighted (IVW) and MR-Egger methods, and further ensured the reliability of the results of dilated cardiomyopathy using three methods: Weighted median, Simple mode, and Weighted mode. Results: Twelve immune phenotypes were considered to have a stable causal relationship with dilated cardiomyopathy. Among them, eight were associated with a reduced risk of dilated cardiomyopathy, including B cell%lymphocyte, CD20 on IgD+CD38-, CD25 on IgD-CD38dim, CD27 on CD20-CD38-, CD38 on IgD-CD38br, CD28 on secreting Treg, CD25 on CD39+secreting Treg, and SSC-A on HLA DR+CD8br; four were associated with an increased risk of dilated cardiomyopathy, including CD45RA+CD8br AC, CD8br AC, CD127 on CD8br, and CD45RA on naive CD4+. Conclusion: Through the method of Mendelian randomization, we demonstrated that twelve immune cell phenotypes have significant causal relationships with dilated cardiomyopathy, providing new insights and ideas for the role of immune cells in the pathogenesis of dilated cardiomyopathy.
Keywords：dilated cardiomyopathyimmune cellsMendelian randomization
Publication Date：2025-11-10
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：5( 3326-3330 )