Exploration of the Hypolipidemic Mechanism and Potential Pharmacodynamic Components of Gualou Xiebai Banxia Decoction Based on Network Pharmacology and Molecular Docking Technology
JIANG Xu
WANG Yuqing
LI Shujiao
WANG Xiaoyu
ZHUANG Guo
Abstract：Objective:The potential pharmacodynamic components and mechanism of Gualou Xiebai Banxia Decoction(GXB)in lipid-lowering effects were explored based on network pharmacology and molecular docking.Methods:The chemical components of GXB were screened through the traditional Chinese medicine system pharmacology database(TCMSP)database and literature.Component targets were obtained using the PharmMapper database.The relevant disease targets of hyperlipidemia were obtained by the Human Mendelian Genetics Database(OMIM),the Human Gene Database(GeneCards).The intersection of component targets and disease targets was taken to obtain potential therapeutic targets.Network of protein-protein interactions(PPI)was constructed through the STRING database and the core targets were screened out.The potential therapeutic targets were subjected to gene ontology(GO)functional analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathway enrichment analysis using Cytoscape software,and a"traditional Chinese medicine-component-target-pathway"network was constructed.The Discovery Studio software was used,molecular docking was conducted between the active ingredients and the core target to screen for potential efficacy components.Results:The network pharmacology method identified 65 chemical components,76 potential therapeutic targets,and 31 core targets in GXB.The GO function analysis yielded 253 entries.The KEGG enrichment analysis yielded 31 signaling pathways.Molecular docking identified 32 potential active ingredients.The study verified that the potential active ingredients in GXB showed strong binding activity with the core target.Conclusion:GXB may exert its effects through potential pharmacological components such as quercetin,apigenin,lycorine,and eugenol on core targets such as serum albumin(ALB),retinoic acid receptor RXR-α(RXRA),peroxisome proliferator-activated receptor α(PPAPA),regulating signaling pathways such as peroxisome proliferator-activated receptor(PPAR),hypoxia-inducible factor(HIF-1),and phenylalanine metabolism,influencing lipid synthesis,breakdown and absorption,thereby promoting lipid metabolism,fatty acid binding and transportion,and exerting its lipid-lowering effect.
Keywords：lipid loweringGualou Xiebai Banxia Decoctionmechanismpharmacodynamic componentsnetwork pharmacologymolecular docking
Publication Date：2025-11-10
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：9( 3212-3220 )