The Efficacy and Medication Rules of Traditional Chinese Medicine in Improving Energy Metabolism in Patients with Chronic Heart Failure Based on Meta-analysis and Data Mining
SHEN Xinyu
REN Shumeng
TENG Yu
SU Sha
ZHAO Mingjing
Abstract：Objective:To evaluate the effect of traditional Chinese medicine on energy metabolism in patients with chronic heart failure and explore its medication rules.Methods:The databases including China National Knowledge Infrastructure(CNKI),WanFang Journal Database,VIP Chinese Journal Database,SinoMed,PubMed,Web of Science,Cochrane Library,and EMbase were searched for randomized controlled trials(RCTs)of traditional Chinese medicine for improving energy metabolism in patients with chronic heart failure.Two researchers independently conducted article screening,data extraction and quality assessment based on inclusion and exclusion criteria.Meta-analysis was performed using Review Manager 5.4.Data mining for medication rules was performed using Microsoft Excel,SPSS Modeler 18.0,and IBM SPSS Statistics 26.0.Results:A total of 18 articles were ultimately included,involving 1 767 patients.Compared with the group treated with western medicine alone,the combination of traditional Chinese medicine and western medicine effectively reduced myocardial energy expenditure(MEE)(MD=-9.51,95%CI-11.51--7.52,P＜0.000 01),further decreased circumferential endsystolic stress(cESS)(MD=-21.38,95%CI-27.57--15.19,P＜0.000 1),at the same time lowered the level of free fatty acids(FFA)(MD=-0.16,95%CI-0.19--0.13,P＜0.000 01),reduced lactate levels in the body(MD=-0.54,95%CI-0.93--0.14,P=0.007).Analysis of medication patterns revealed that the top 10 in frequency were ginseng radix,salviae miltiorrhizae radix-astragali radix,semen lepidii,leonuri herba,aconiti tuber laterale,cinnamomi ramulus,lycopi herba,radix notoginseng,and poria.The analysis of flavor and meridian tropism showed that the drug mainly belonged to the heart,spleen and lung meridian.All drugs were mainly warm,and the medicinal flavor was mostly sweet.The most commonly used tonifying drugs were observed.The commonly used drug pairs were astragali radix-salviae miltiorrhizae radix,astragali radix-semen lepidii,radix notoginseng-astragali radix-salviae miltiorrhizae radix and astragali radix-ginseng radix-salviae miltiorrhizae radix.Three clusters were obtained from cluster analysis.The first cluster contained leonuri herba,lycopi herba,radix notoginseng and semen lepidii.The second cluster contained astragali radix,salviae miltiorrhizae radix and ginseng radix.The third cluster contained cinnamomi ramulus,poria,atractylodis macrocephalae rhizoma,glycyrrhizae radix and aconiti tuber laterale.Conclusion:Combination of traditional Chinese medicine and western medicine can significantly improve the energy metabolism of patients with chronic heart failure,which is conducive to the reduction of MEE,cESS,FFA and lactate.The core treatment for improving energy metabolism in patients with heart failure is to invigorate Qi,warm Yang,promote blood and water circulation.The core drugs include astragali radix,ginseng radix,radix notoginseng,salviae miltiorrhizae radix,semen lepidii,leonuri herba,cinnamomi ramulus and aconiti tuber laterale.Due to the limited number of related literatures and low-quality evaluation,there is some bias,and further high-quality research is needed for validation.
Keywords：heart failureenergy metabolismtraditional Chinese medicineMeta-analysismedication rule
Publication Date：2025-11-10
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：11( 3201-3211 )