The Mechanism of Dachengqi Decoction in the Treatment of Intracerebral Hemorrhage Based on Network Pharmacology and Molecular Docking
DUAN Yang
LONG Miaoqing
WANG Yi
CHENG Xueqin
YAN Yizhi
JIANG Yichen
LIN Li
ZENG Peng
Abstract：Objective:Based on network pharmacology and molecular docking,the mechanism of Dachengqi Decoction in the treatment of intracerebral hemorrhage(ICH)was explored.Methods:The blood-entering components of Dachengqi Decoction were collected by artificial text mining method to evaluate the pharmacological parameters and safety of the blood-entering components.The action targets of the blood-entering components of Dachengqi Decoction were collected using the PubChem database.Gene ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were conducted to explore the potential mechanism of Dachengqi Decoction in resisting ICH.The interaction between the blood-entering components of Dachengqi Decoction and the anti-ICH targets was verified by molecular docking.Results:A total of 11 blood-entering components of Dachengqi Decoction were obtained.Among them,emodin,rhein,chrysophanol,aloe-emodin,hesperidin,naringin,magnolol,and honokiol,these 8 components were the Q-markers of this formula.There were 94 targets for treating ICH in the blood-entering components of Dachengqi Decoction,naringin,emodin,hesperidin,hesperetin,honokiol,and honokiol were the main active ingredients for the treatment of ICH.The blood-entering components of Dachengqi Decoction could regulate various pathophysiological processes of the occurrence and development of ICH,such as neuroinflammation-related pathways,angiogenesis-related pathways,and pathways related to Alzheimer's disease(hsa05010)and neuronal death,among them,targeting neuroinflammation was the key mechanism of Dachengqi Decoction in the treatment of ICH.Naringin,emodin,hesperidin,honokiol,and hesperetin were the main blood-entering components targeting neuroinflammation.In addition,Dachengqi Decoction not only showed therapeutic effect during the acute and subacute stages of ICH,but also could influence the pathology of Aβ and Tau,and improve the secondary cognitive dysfunction of ICH in the recovery stage.Conclusion:The 11 blood-entering components of Dachengqi Decoction showed better pharmacological parameters and high safety.The main blood-entering components for the treatment of ICH are naringin,emodin,hesperidin,hesperetin,honokiol and honokiol.The main mechanism involves microglial cell-mediated neuroinflammation.
Keywords：intracerebral hemorrhageneuroinflammationblood-entering componentscognitive dysfunctionQ-Marker
Publication Date：2025-09-10
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：8( 2609-2616 )