Exploration of the Mechanism of Yixin Kangtai Capsule in the Treatment of Coronary Heart Disease Angina Pectoris Based on Network Pharmacology and Molecular Docking
HU Ting
ZHANG Ning
LIU Luyao
JIAO Xueyan
ZHANG Yifan
CHEN Yun
LAN Zhenzhen
LIU Xincan
Abstract：Objective:To explore the mechanism of action of Yixin Kangtai Capsule in the treatment of coronary heart disease angina pectoris based on network pharmacology and molecular docking.Methods:The active ingredients and corresponding targets of Yixin Kangtai Capsule were obtained from CNKI,WanFang,TCMSP,and HERB platforms,and the targets related to coronary heart disease angina pectoris were obtained from GeneCards,DisGeNET,and OMIM databases.The potential mechanism of Yixin Kangtai Capsule for the treatment of angina pectoris was investigated by network pharmacology methods,target prediction,protein-protein interaction(PPI)data collection,network construction,network analysis,and enrichment analysis.Molecular docking simulation was performed to analyze the interaction between Yixin Kangtai capsule and the core target.Results:One hundred and three active ingredients of Yixin Kangtai capsule were obtained,corresponding to 251 targets,2 011 targets related to angina pectoris,and 149 intersecting targets of Yixin Kangtai capsule.The results of gene ontology(GO)analysis showed that the potential biological processes of Yixin Kangtai Capsule in the treatment of angina pectoris included lipopolysaccharide response,positive regulation of gene expression,and negative regulation of apoptosis.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified advanced glycation endproducts(AGE)-receptor for AGE(RAGE)signaling pathway,interleukin(IL)-17 signaling pathway,tumor necrosis factor(TNF)signaling pathway and other related pathways.The molecular docking results showed that quercetin,isoglycol,glycyrrhizinone,zeylanol,and huarangiin,the main active ingredients of Yixin Kangtai Capsule for the treatment of angina pectoris,docked well with the core proteins,HSP90AA1,tumor suppressor factor P53(TP53),epidermal growth factor receptor(EGFR),signal transducer and activator of transcription 3(STAT3),and JUN.Conclusion:Yixin Kangtai Capsule may play some role in the treatment of coronary heart disease angina pectoris through anti-inflammation,attenuating myocardial ischemia-reperfusion injury,and inhibiting neovascularisation.
Keywords：coronary heart diseaseangina pectorisYixin Kangtai Capsulenetwork pharmacologymolecular docking
Publication Date：2025-08-10
Online Publishing Date：2025-08-20(First online date of this platform, not the publication date of the document)
Pages：9( 2241-2249 )