Pharmacokinetic Analysis of the Components of Shenyuan Yiqi Huoxue Capsules
LOU Yan
XING Wenlong
LIU Hongxu
SHANG Juju
GONG Tao
HAN Xuyang
LI Xiang
LIAN Yanjie
Abstract：Objective:To explore the pharmacokinetic effects of the Shenyuan Yiqi Huoxue Capsules(SYYQ)on the active components of astragaloside,tetrahydropalmatine and tanshinone Ⅱ A.Methods:Twenty-four healthy Wistar rats were divided into the SYYQ group,the Astragalus monotherapy group,the Salvia miltiorrhiza monotherapy group,and the corydalis rhizome monotherapy group,with 6 rats in each group.Blood samples were collected at 5,15,30 minutes,and 1,1.5,2,3,4,6,8,12,16,and 24 hours after invalation.The blood concentrations of astragaloside,tetrahydropalmatine,and tanshinone Ⅱ A were determined by ultra-performance liquid chromatography-mass spectrometry(PLC-MS/MS),and the dynamic parameters were calculated and the drug time curves were plotted.Results:Compared with the monotherapy group,the time to peak(Tmax)of astragaloside in the SYYQ compound delayed(P＜0.05),and there were two absorption peaks in the pharmacokinetics of astragaloside and tanshinone Ⅱ A.The peak concentration(Cmax)of astragaloside increased(P＜0.01),while the Cmax of tetrahydropalmatine decreased(P＜0.01).The area under the drug duration curve0-t(AUC0-T)and the area under the drug duration curve0-∞(AUC0-∞)of astragaloside increased(P＜0.05 or P＜0.01),while the AUC0-T and AUC0-∞ of tanshenone Ⅱ A and tetrahydropalmatine were smaller than those of the monotherapy group(P＜0.05 or P＜0.01).The drug half-life(T1/2)and mean residence time(MRT0-t)of astragaloside increased(P＜0.05 or P＜0.01),the T1/2 and MRT0-t of monotherapy decreased(P＜0.01),and the T1/2 of tanshinone Ⅱ A increased(P＜0.01).Conclusion:The absorption distribution,retention and elimination of astragaloside,tetrahydropalmatine and tanshinone Ⅱ A in Shenyuan Yiqi Huoxue Capsules were different from those in the monotherapy group,suggesting that the formula combination of Shenyuan Yiqi Huoxue Capsules could increase the concentration of astragaloside,exert some sustained-release effect,reduce the component concentrations of tetrahydropalmatine and tanshinone Ⅱ A,and change their distribution and elimination rate.This compatibility relationship might enable the traditional Chinese medicine formula to have the effect of enhancing efficacy and synergy.
Keywords：Shenyuan Yiqi Huoxue CapsulesChinese patent medicinecombination and compatibility of formulaspharmacokineticsratsexperimental study
Publication Date：2025-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 2121-2127 )