The Mechanism of Ginseng-Poria Medicinal Combination for Treating Alzheimer's Disease Based on Network Pharmacology and Molecular Docking Technology
ZHOU Mengling
WANG Yanli
YU Borui
Abstract：Objective:To explore the mechanisms of Ginseng-Poria medicinal combination for the treatment of Alzheimer's disease(AD)Based on network pharmacology and molecular docking technology.Methods:The active components of Ginseng-Poria medicinal combination were predicted and screened under the conditions of oral bioavailability(OB)and drug-likeness(DL)using the Traditional Chinese Medicine System Pharmacology Technology Platform(TCMSP).The action targets related to the treatment of AD were collected through the GeneCards database.The component-target and target-protein interaction network diagrams were constructed using the DAVID database and Cytoscape 3.8.2 software.The target genes were analyzed for gene ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis,and the core components and core targets in the pharmacological network were subjected to molecular docking.Results:The active components in Ginseng-Poria medicinal combination were analyzed using the TCMSP database,mainly including kaempferol,β-sitosterol,and stigmasterol.lt acted on 76 targets related to AD,including tumor necrosis factor(TNF),peroxisome proliferative activity receptor γ(PPARG),interleukin-1β(IL-1β),nitric oxide synthase 3(NOS3),and JUN proto-oncogene(JUN),through 79 the neuroactive ligand-receptor interaction pathway,calcium signaling pathway,cholinergic synapses,and dopaminergic synapses.It participated in 215 biological processes including cholinergic synaptic energy transmission,drug response,acetylcholine-related receptors,and positive regulation of cell proliferation,exerting the therapeutic effect.The results of molecular docking showed that the main active ingredients screened with better binding activity and the important targets.Conclusion:Ginseng-Poria medicinal combination for treating AD showed the characteristics of multiple components,multiple pathways,and multiple targets.
Keywords：Alzheimer's diseaseGinseng-Poria medicinal combinationnetwork pharmacologymolecular dockingmechanism
Publication Date：2025-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 2112-2120 )