Medication Rules of the Patented Traditional Chinese Medicine Compound Formula for Treating Coronary Heart Disease of Angina Pectoris
ZHANG Chaorong
YAN Jiaqi
YAN Xia
Abstract：Objective:To explore the medication and compatibility rules of the authorized traditional Chinese medicine patent compound formula for treating angina pectoris of coronary heart disease as the preferred compound prescriptions,providing preliminary references for the research and development of traditional Chinese medicine new drugs and the protection of traditional Chinese medicine patents.Methods:All data of authorized traditional Chinese medicine patent compound formula for treating angina pectoris of coronary heart disease were collected from the China Patent Publication Website of the National Intellectual Property Administration.The data organization and frequency statistics were performed by Excel 2016.Apriori association rule analysis and systematic clustering analysis were conducted respectively using IBM SPSS Modeler 18.0 and SPSS 25.0,and the complex network of core traditional Chinese medicine was constructed by Cytoscape 3.10.Results:A total of 215 preferred traditional Chinese medicine patented compound prescriptions were included,involving 275 kinds of drugs,mainly invigorating blood and dissolving stasis drugs,supplement and boost drugs.The commonly used traditional Chinese medicine included Salvia miltiorrhiza(113 times,accounting for 52.56％),Ligusticum Chuanxiong(84 times,accounting for 39.07％),Notoginseng(73 times,accounting for 33.95％),Astragalus membranaceus(61 times,accounting for 28.37％).The commonly used antidrugs were Ligusticum Chuanxiong-Red Peony Root(37 times,accounting for 17.21％),Salvia miltiorrhiza-Pueraria lobata(33 times,accounting for 15.35％),Ligusticum Chuanxiong-Angelica Sinensis(32 times,accounting for 14.88％),Salvia miltiorrhiza-Ophiopogon japonicus(27 times,accounting for 12.56％),Salvia miltiorrhiza-Hawthorn(24 times,accounting for 11.16％).Commonly used horn traditional Chinese medicine included Salvia miltiorrhiza-Safflower-Ligusticum Chuanxiong(32 times,accounting for 14.88％),Ligusticum Chuanxiong-Pueraria lobata-Salvia miltiorrhiza(27 times,accounting for 12.56％),Safflower-Red Peony Root-Ligusticum Chuanxiong(27 times,accounting for 12.56％),Salvia miltiorrhiza-Red Peony Root-Ligusticum Chuanxiong(27 times,accounting for 12.56％),Astragalus membranaceus-Angelica sinensis-Ligusticum Chuanxiong(23 times,accounting for 10.70％).High-confidence association rules included"Pueraria lobata-Ligusticum Chuanxiong→Salvia miltiorrhiza""Red Peony Root-Salvia miltiorrhiza→Ligusticum Chuanxiong""Pueraria lobata→Salvia miltiorrhiza".The core ingredients included Salvia miltiorrhiza,Ligusticum Chuanxiong,Astragalus membranaceus,Notoginseng,Safflower,Earthworm,Red Peony Root,Angelica sinensis.Conclusion:The preferred traditional Chinese medicine patented compound formula for treating coronary heart disease of angina pectoris mainly focused on boosting Qi,invigorating blood and dissolving stasis.It also taked into account the process of"heat accumulation in the blood vessels"of coronary heart disease with bitter and cold herbs to clear the stasis and heat.
Keywords：coronary heart diseaseangina pectorispatenttraditional Chinese medicine compound formuladata mining
Publication Date：2025-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 2103-2111 )