Correlation of TyG,FAR and RPR with the Severity of Coronary Artery Lesions in Patients with Coronary Heart Disease

SUN Xiuxia; REN Yanqin

doi:10.12102/j.issn.1672-1349.2025.13.014

Abstract：Objective: To analyze the correlation and application value of triglyceride-glucose index (TyG), fibrinogen/serum albumin (FAR) index, and red blood cell distribution width (RDW)/platelet (RPR) index with the severity of coronary artery lesions in patients with coronary heart disease (CHD). Methods: A total of 252 patients with CHD hospitalized in the Department of Cardiology at Fenyang Hospital of Shanxi Province from October 2021 to October 2022 were selected as the study subjects. Among them, 210 patients with coronary artery stenosis confirmed by coronary angiography were classified into the CHD group, while 42 patients without coronary artery stenosis were selected as the control group. General data, including gender, age, smoking history, alcohol consumption history, hypertension history, diabetes history, and medication history, were collected. Laboratory test results within 24 hours of admission, including blood routine, liver function, coagulation series, renal function, lipid series, thyroid function series, and blood glucose, were also collected. According to the Gensini score, the CHD group was divided into mild group (72 cases, Gensini score ≤30), moderate group (72 cases, 30 < Gensini score ≤75), and severe group (66 cases, Gensini score >75). According to the number of coronary artery lesions, the CHD group was divided into single-vessel lesion group (50 cases), double-vessel lesion group (52 cases), and multi-vessel lesion group (108 cases). Spearman's method was used to analyze the correlation between TyG, FAR, and RPR with the severity of coronary artery lesions in CHD patients. Receiver operating characteristic (ROC) curves were drawn to evaluate the predictive value and diagnostic efficiency of TyG, FAR, and RPR for severe coronary artery lesions. Results: The values of TyG, FAR, and RPR in the CHD group were significantly higher than those in the control group (P < 0.001). There were statistically significant differences in TyG, FAR, and RPR values among patients with different numbers of coronary artery lesions (P < 0.05). The single-vessel lesion group had the lowest TyG, FAR, and RPR values, followed by the double-vessel lesion group, while the multi-vessel lesion group had the highest values, with statistically significant differences between each pair (P < 0.05). The TyG, FAR, and RPR values in the severe, moderate, and mild groups according to Gensini scores decreased sequentially, with statistically significant differences (P < 0.001). In CHD patients, Gensini scores were positively correlated with TyG, RPR, and FAR (r values of 0.483, 0.644, and 0.822, respectively; P < 0.001). The number of coronary artery lesions was positively correlated with TyG and FAR (r values of 0.294 and 0.374, respectively; P < 0.001). In patients with severe CHD lesions, the area under the curve (AUC) for TyG was 0.767, with a sensitivity of 84.8% and specificity of 56.9%; for FAR, the AUC was 0.929, with a sensitivity of 93.9% and specificity of 81.9%; and for RPR, the AUC was 0.871, with a sensitivity of 83.3% and specificity of 81.9%. Conclusion: TyG, FAR, and RPR can effectively reflect the degree of coronary artery stenosis and can serve as reliable indicators for assessing the severity of coronary artery lesions.