Research Progress on the Role of HMGB1 in the Pathogenesis of Traumatic Brain Injury
LI Shuqing
JI Bing
Abstract：This review summarizes the biological characteristics of high mobility group box 1 (HMGB1) and its role in the pathophysiological mechanisms of traumatic brain injury (TBI), aiming to provide insights for research and treatment of TBI. TBI is a serious disease that poses a major threat to human health and social economy, characterized by high incidence, high disability rate, high mortality, and poor prognosis. HMGB1 is a non-histone DNA-binding protein that participates in various life activities such as intracellular DNA recombination, repair, and gene transcription regulation. In recent years, increasing studies have found that HMGB1 plays an important role in the pathogenesis of TBI. As an early damage-associated molecular pattern (DAMP), HMGB1 participates in multiple pathological processes after TBI, including ischemic brain injury, inflammatory response, coagulation disorders, formation of cerebral edema, and secondary brain injury.
Keywords：traumatic brain injurysecondary brain injuryhigh mobility group protein 1inflammatory responsereviews
Publication Date：2025-07-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1990-1994 )