Risk-benefit Evaluation of Modified Jiming Powder Combined with Reamebao in the Treatment of Heart Failure with Diuretic Resistance Based on Multi-criteria Decision
YANG Jinxing
LI Changyuan
ZHAO Na
ZHANG Dunhan
LI Shi
ZHANG Lei
LI Na
HAO Xiangchun
Abstract：Objective: To evaluate the risk-benefit of modified Jiuming powder combined with traditional Chinese medicine hot fomentation in the treatment of patients with heart failure and diuretic resistance based on multi-criteria decision making. Methods: A total of 144 patients with heart failure and diuretic resistance who were treated at Funing District TCM Hospital, Qinhuangdao City from March 2020 to March 2023 were selected as the study subjects. The patients were randomly divided into an observation group (72 cases) and a control group (72 cases) according to the random number table method. The observation group received modified Jiuming powder combined with traditional Chinese medicine hot fomentation, while the control group received only traditional Chinese medicine hot fomentation. A multi-criteria decision-making model for the treatment of heart failure with diuretic resistance was established. Results: Compared with the control group, the left ventricular ejection fraction (LVEF) and activated partial thromboplastin time (APTT) in the observation group were significantly increased (P < 0.05), while the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), D-dimer (D-D), fibrinogen (FIB), matrix metalloproteinase-9 (MMP-9), and myeloperoxidase (MPO) were significantly decreased (P < 0.05). The total effective rate of clinical efficacy in the observation group was higher than that in the control group (88.9% vs. 69.4%, P < 0.05), and the incidence of adverse reactions was lower (6.94% vs. 18.05%, P < 0.01). The benefit-risk evaluation results showed that compared with the control group, the treatment effect of the observation group was significantly better, with greater advantages in improving cardiac function, coagulation function, and inflammatory response. The incidence of major adverse cardiovascular events (MACE) and adverse reactions was significantly reduced. Conclusion: The treatment of patients with heart failure and diuretic resistance using the modified Jiuming powder combined with traditional Chinese medicine hot fomentation is more effective, and can significantly improve the cardiac function of the patients.
Keywords：heart failurediuretic resistancemodified Jiming PowderReamebaomulti-criteria decisionrisk-benefit
Publication Date：2025-06-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 1693-1700 )