The Influence of NF-κB Pathpath-mediated Inflammatory Response on Myocardial Hypertrophy and an Overview of Traditional Chinese Medicine Intervention
ZHANG Peipei
LIU Yu
ZHANG Yongbo
TIAN Yanan
BI Yingfei
Abstract：This review focuses on the nuclear factor kappa B (NF-κB) mediated inflammatory signaling pathway and the advantages of compound Chinese medicines in anti-inflammatory effects, immune enhancement, and cardiovascular protection. When the heart is stimulated, the NF-κB signaling pathway is activated, releasing inflammatory mediators such as interleukin 6 (IL-6), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α), which promote the occurrence and development of myocardial hypertrophy. Inhibiting the activation of the NF-κB signaling pathway to reduce immune inflammatory responses is an important approach in the treatment of myocardial hypertrophy.
Keywords：myocardial hypertrophyinflammatory responsemolecular mechanismChinese medicinereview
Publication Date：2025-06-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1671-1676 )