Predictive Value of D-dimer,NT-proBNP and eGFR in Patients with Atrial Fibrillation Complicated with Thromboembolism
WANG Bin
HU Dan
WANG Fangfang
SUN Shuang
Abstract：Objective: To explore the predictive value of D-dimer (D-D), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and estimated glomerular filtration rate (eGFR) for thromboembolism (TE) in patients with atrial fibrillation. Methods: A total of 242 patients with atrial fibrillation admitted to our hospital from March 2020 to July 2022 were selected as the study subjects. According to transesophageal echocardiography and other examination results, the patients were divided into a TE group (36 cases) and a non-TE group (206 cases). The levels of D-D, NT-proBNP, and eGFR upon admission were recorded, and differences in related indicators between the two groups were compared. Univariate and multivariate logistic regression analyses were used to screen risk factors for TE in patients with atrial fibrillation. Receiver operating characteristic (ROC) curves were drawn to analyze the predictive value of combined detection of D-D, NT-proBNP, and eGFR for TE in patients with atrial fibrillation. Results: The proportion of patients with primary hypertension, left atrial diameter, D-D, and NT-proBNP levels were higher in the TE group than in the non-TE group, while left ventricular ejection fraction (LVEF), high-density lipoprotein cholesterol (HDL-C), and eGFR were lower in the TE group, with all differences being statistically significant (P < 0.05). Logistic regression analysis showed that LVEF, D-D, NT-proBNP, and eGFR were all influencing factors for TE in patients with atrial fibrillation (P < 0.05). ROC curve analysis showed that the area under the curve (AUC), sensitivity, and specificity of combined prediction by D-D, NT-proBNP, and eGFR for TE in patients with atrial fibrillation were 0.859, 82.90%, and 78.60%, respectively, which were better than those of individual predictions (P < 0.05). Conclusion: D-D, NT-proBNP, and eGFR can serve as predictive factors for TE in patients with atrial fibrillation, and their combined predictive value is higher.
Keywords：atrial fibrillationthromboembolismD-dimerN-terminal pro-brain natriuretic peptideestimated glomerular filtration rateinfluencing factor
Publication Date：2025-05-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1548-1552 )