Research Progress of Regulating Mitochondria by Traditional Chinese Medicine in the Treatment of Heart Failure
ZHANG Yibo
LU Jianqi
Qi Xiang
MAO Meiling
ZHANG Zheng
LU Wei
ZHANG Yunli
CHEN Lidan
CHEN Jiayong
Abstract：This review summarizes the research progress on the pathophysiological mechanisms of heart failure and analyzes the clinical study data of active components and classical compound prescriptions of traditional Chinese medicine. As the terminal stage of cardiovascular disease development, heart failure still faces great challenges in clinical treatment. Although modern medicine has made significant progress in the field of cardiovascular diseases, conventional chemical drugs still show unsatisfactory effects in reducing the mortality rate of patients with heart failure. Traditional Chinese medicine, with its advantages of multi-component synergistic action and multiple mechanisms of action, has shown unique efficacy in improving the clinical symptoms of patients with heart failure. TCM can exert cardioprotective effects by regulating calcium ion homeostasis in myocardial cells, inhibiting oxidative stress reactions, and regulating mitochondrial autophagy.
Keywords：heart failuremitochondriontraditional Chinese medicinereview
Publication Date：2025-05-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1344-1349 )