Effect of Reperfusion Injury and Prognosis of Acute Myocardial Infarction after Interventional Operation with Tanyu Tongzhi Formula

QI Jiayu; WU Feng; FAN Min

doi:10.12102/j.issn.1672-1349.2025.09.003

Abstract：Objective:To explore the effectiveness of Tanyu Tongzhi Formula in improving myocardial reperfusion injury after interventional operation of acute myocardial infarction and its influence on prognosis.Methods:A total of 150 patients with acute myocardial infarction were randomly divided into experimental group(73 cases)and control group(77 cases)by double-blind principle.In addition to the basic treatment of acute myocardial infarction,the experimental group was given Tanyu Tongzhi Formula,and the control group was given placebo.General data of patients were collected,including myocardial injury markers and peak time before surgery,at 6,12,18,and 24 h after surgery.The decrease of ST segment in ECG 2 h after operation was recorded.Cardiac ultrasound results were recorded at the 7th and 6th month after operation.Major adverse cardiovascular events(MACE)were recorded in both groups within 6 months.Results:Before treatment,there was no significant difference in plasma cardiac troponin Ⅰ(cTnⅠ),creatine kinase isoenzyme(CK-MB),and myoglobin(MYO)between 2 groups(P＞0.05).There was significant difference in cTnⅠ at 12,18 h after operation between the two groups(P＜0.05).There was no significant difference in cTnⅠ at 6 and 24 h after operation(P＞0.05).The difference of MYO at 6 h after operation between the two groups was statistically significant(P＜0.05).There was no significant difference in MYO between the two groups at 12,18,and 24 h after surgery(P＞0.05).There was no significant difference in CK-MB between the two groups at 6,12,18,and 24 h after surgery(P＞0.05).There was no significant difference in the peak time of cTnⅠ and CK-MB between the two groups(P＞0.05).The peak time of MYO in experimental group was shorter than that in the control group(P＜0.05).There was statistical significance in ST regression rate of ECG at 2 h after operation between the two groups(P＜0.05).There was no significant difference in left ventricular brachy-axis shortening rate(LVFS),left ventricular ejection fraction(LVEF),and LVED between the two groups on the 7th day after surgery(P＞0.05).At 6 months after operation,LVEF in experimental group was higher than that in the control group,and the difference was statistically significant(P＜0.05).at the 7th day after surgery,there were no significant differences in global longitudinal strain(GLS),global circumferential strain(GCS),global radial strain(GRS),and global area strain(GAS),between the two groups(P＞0.05).There was statistical significance in the incidence of MACE between two groups(P＜0.05).Conclusion:Tanyu Tongzhi Formula Shows significant myocardial protection in the pathological environment of ischemia-reperfusion,with tendency to improve the cardiac function in the short term,and improves the prognosis of patients in the long term.