The Pathological Characteristics of Cardiovascular Calcification in Chronic Kidney Disease Stages 3-5 Non-dialysis Patients
LIN Changwei
YUAN Xinzhu
YUAN Zujun
Abstract：Objective:To analyze the pathological characteristics and personalized management strategies of cardiovascular calcification in chronic kidney disease(CKD)stage 3-5 non-dialysis patients.Methods:A total of 157 patients with stage 3-5 CKD admitted to our hospital from May 2020 to May 2023 were selected as the study subjects.The clinical data of CKD stages 3-5 patients were compared,and the pathological characteristics of cardiovascular calcification in these patients were analyzed.Additionally,the independent risk factors affecting the occurrence of cardiovascular calcification were analyzed,and a column chart model was built to verify its effectiveness.Results:In CKD stage 3-5 patients,Hypersensitive C-reactive protein(hs-CRP),serum creatinine(Cr),and blood phosphorus increased significantly,and blood calcium decreased significantly.From stage 3 to stage 5 of CKD,the rate of reaching the standard for blood calcium and phosphorus in patients significantly decreased(P＜0.05).The proportion of inconspicuous coronary artery calcification decreased gradually,while the proportion of severe coronary artery calcification increased gradually.The severity of abdominal aortic calcification gradually increased.Age,hypertension,diabetes,hs-CRP,ALP,blood phosphorus,and blood calcium levels were independent risk factors for cardiovascular calcification in non-dialysis CKD patients at stages 3-5(P＜0.05).The area under the receiver operating characteristic curve of the nomogram model was 0.807,and the C-index was 0.812.The calibration curve fits well.The threshold probability of the clinical decision curve showed a high net benefit value in the range of 0.04-0.91,indicating that the nomogram model showed high discrimination,better accuracy,and calibration,and was safe and reliable.Conclusion:Cardiovascular calcification occurs early and increases with severity as CKD progresses.Age,hypertension,diabetes,Alb,hs-CRP,ALP,and blood phosphorus levels are all independent risk factors for cardiovascular calcification in non-dialysis CKD patients at stages 3-5.Therefore,individualized treatment strategies should be taken to reduce the incidence of cardiovascular calcification.
Keywords：chronic nephritiscardiovascular calcificationpathological characteristicsprocessing strategy
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1203-1209 )