Meta-analysis of the Efficacy of Type 2 Diabetes Mellitus Combined with Dyslipidemia Treated by Tonifying Qi Nourishing Yin Method
HU Yuxuan
SHANG Juju
LAI Xiaolei
SHI Lixiao
Abstract：Objective:To evaluate the efficacy and safety of the method of tonifying Qi and nourishing Yin combined with conventional Western medicine for treating in patients with type 2 diabetes mellitus and dyslipidemia.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Chinese Journal Literature Service Platform,China Biology Medicine Disc,PubMed database,the Cochrane Library,and the Netherlands Medical Abstracts database were searched from the establishment of the database to September 2023.A comprehensive collection of randomized controlled trials(RCTs)of the intervention of type 2 diabetes mellitus with dyslipidemia using the methool of tonifying Qi nourishing Yin combined with conventional Western medicine(observation group)versus conventional Western medicine alone(control group)was performed.RevMan 5.4 software was used for Meta-analysis of the extracted data.Stata MP16 was used to perform sensitivity analysis of the extracted data,and Egger's test for publication bias was performed in the results of more than 10 included studies.Results:A total of 16 studies were included,involving 1 314 patients.The results of the Meta-analysis showed that the method of tonifying Qi and nourishing Yin combined with conventional Western medicine therapy can increase the overall clinical efficacy(RR=1.29,95％CI 1.19-1.40,P＜0.000 01)and Chinese medicine symptom efficacy(RR=1.34,95％CI 1.23-1.46,P＜0.000 01)more than that of Western medicine therapy alone.Meanwhile,the combination of Chinese and Western medicine was superior to Western medicine alone in improving total cholesterol(MD=-0.42,95％CI-0.57--0.28,P＜0.000 01),triglyceride(MD=-0.60,95％CI-0.77--0.43,P＜0.000 01),high-density lipoproteincholesterol(MD=0.16,95％CI 0.08-0.15,P＜0.000 01),low-density lipoprotein cholesterol(MD=-0.40,95％CI-0.52--0.28,P＜0.000 01),fasting plasma glucose(MD=-0.83,95％CI-1.12--0.54,P＜0.000 01),2 h postprandial blood glucose(MD=-1.18,95％CI-1.62--0.74,P＜0.000 01),and hemoglobin A1c(MD=-0.55,95％CI-0.86--0.24,P＜0.000 01).The differences were statistically significant(all P＜0.05).The publication bias of the included literature was small(P＞0.05),and the results were reliable.Conclusion:Current evidence suggests that the method of tonifying Qi and nourishing Yin combined with the conventional treatment of Western medicine show better effect on enhancing the total effective rate of clinical treatment,improving patients'symptoms,blood lipid,and blood glucose indices,with better safety.However,it still requires high-quality,more standardized clinical randomized controlled trials for further research and analysis.
Keywords：type 2 diabetes mellitusdyslipidemiatonifying Qi and nourishing Yin methodMeta-analysissystematic evaluation
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：16( 1121-1136 )