Clinical Study of Shenfu Longmu Decoction for Treating Ischemic Cardiomyopathy with Acute Heart Failure

ZHAO Qi; GAO Qi; CHE Qifu

doi:10.12102/j.issn.1672-1349.2025.07.014

Abstract：Objective:To observe the effects of Shenfu Longmao Decoction on cardiac blood perfusion,ventricular wall motion,serum growth differentiation factor-15(GDF-15),soluble stromal lysin 2(sST2),and angiotensin 1-7[Ang-(1-7)]in patients with ischemic cardiomyopathy with acute heart failure.Methods:A total of 92 patients with ischemic cardiomyopathy combined with acute heart failure were divided into western medicine group and integrated Chinese and western medicine group by random number table method,with 46 cases in each group.The western medicine group was treated with conventional western medicine,and the integrated Chinese and Western medicine group was treated with Shenfu Longmu Decoction on the basis of Western medicine group.The clinical effects of the two groups were compared,and the changes of traditional Chinese medicine(TCM)syndrome score,left ventricular wall motion score index,cardiac blood perfusion(mean blood flow,perivascular resistance)before and after treatment were observed.Left ventricular mass index,left ventricular ejection fraction,stroke output,E peak deceleration time and Ang-(1-7),sST2,GDF-15,and interleukin33(IL-33)levels were detected before and after treatment in both groups.Results:The total effective rate of integrated Chinese and western medicine group was 97.83%,which was higher than that of the western medicine group(82.61%),the difference was statistically significant(P＜0.05).After treatment,the scores of palpitation,cold body and cold limbs,asthma,shortness of breath,pale complexion,abdominal distension and loose stool,oliguria and edema,and left ventricular wall movement score of the integrated Chinese and western medicine group were lower than those of the western medicine group(P＜0.05),and the perivascular resistance was lower than that of the western medicine group(P＜0.05),the mean blood flow,stroke output and left ventricular ejection fraction were higher than those in the western medicine group(P＜0.05),and the peak deceleration time of E,left ventricular mass index and serum levels of Ang-(1-7),sST2,GFD-15,and IL-33 in integrated Chinese and western medicine group were lower than those in the western medicine group(P＜0.05).Conclusion:In the treatment of patients with ischemic cardiomyopathy and acute heart failure,Shenfu Longmu Decoction can inhibit inflammatory injury,improve cardiac blood perfusion,reduce ventricular remodeling,improve ventricular wall motor function,heart function and clinical efficacy.