Efficacy and Safety of Combined Traditional Chinese and Western Medicine in Treating Qi-deficiency and Blood-stasis Syndrome of Coronary Heart Disease:a Meta-analysis
HU Yinhua
SUN Longfei
Nijiati·Maimaitijiang
AN Dongqing
XIE Xiaoliu
Abstract：Objective:To evaluate the efficacy and safety of integrated traditional Chinese and western medicine in treating Qi-deficiency and blood-stasis syndrome of coronary heart disease.Methods:Randomized controlled trials on the treatment of Qi-deficiency and blood-stasis of coronary heart disease by integrated Chinese and Western medicine were included in China Biomedical Literature Database(CBM),China National Knowledge Network(CNKI),WanFang Database and Chinese Science and Technology Journal Full-text Database(VIP)from June 2013 to June 2023 were searched.Cochrane bias risk assessment criteria were used to evaluate the methodological quality of included studies from randomization,assignment,concealment,blinding,withdrawal and loss of follow-up.RevMan 5.4 software was used to summarize and analyze the data included in the literature.Results:Finally,29 studies were included,involving 3 554 patients.Compared with conventional treatment with western medicine alone,the combination of Chinese and western medicine could improve the curative effect of TCM syndrome(OR=6.07,95%CI 2.92-12.62,P＜0.000 01)and electrocardiogram(OR=3.27,95%CI 2.30-4.63,P＜0.000 01),efficacy of angina pectoris(OR=4.69,95%CI 3.47-6.36,P＜0.000 01),clinical efficacy(OR=3.93,95%CI 2.93-5.25,P＜0.000 01),reduction rate of nitroglycerin(OR=5.20,95%CI 1.76-15.32,P=0.003),decrease TCM syndrome score(MD=-3.43,95%CI-4.54--2.33,P＜0.000 01),chest tightness score(MD=-1.15,95%CI-1.77--0.54,P=0.000 3),chest pain score(MD=-0.98,95%CI-1.54--0.43,P=0.000 5),shortness of breath score(MD=-0.68,95%CI-1.09--0.27,P=0.001),incidence of endpoint events(OR=0.27,95%CI 0.12-0.61,P=0.002),decrease total cholesterol(MD=-0.74,95%CI-0.96--0.51,P＜0.000 01),triglyceride(MD=-0.61,95%CI-0.97--0.25,P=0.000 9),low density lipoprotein cholesterol(MD=-0.61,95%CI-0.72--0.50,P＜0.000 01),and increase high density lipoprotein cholesterol(MD=0.13,95%CI 0.01-0.24,P=0.03).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.29).Conclusion:Existing studies have shown that traditional Chinese medicine combined with western medicine shows more advantages for the treatment of coronary heart disease syndrome of Qi-deficiency and blood-stasis than western medicine alone.
Keywords：coronary heart diseaseQi-deficiency and blood-stasis syndromeintegration of traditional Chinese and western medicinerandomized controlled trialsMeta-analysis
Publication Date：2025-04-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 991-1000 )