Systemat ic Evaluation of the Efficacy and Safety of Tongxinluo Combined with Statin for the Treatment of Unstable Angina Pectoris Dyslipidemia
ZHANG Chenhao
WANG Jia
REN Ruhua
LIU Yiying
GAO Meili
WANG Ming
Abstract：Objective:To evaluate the efficacy and safety of Tongxinluo combined with statin for the treatment of unstable angina pectoris dyslipidemia.Methods:Randomized controlled trials(RCT)of Tongxinluo combined with statin for the treatment of unstable angina pectoris dyslipidemia were collected by searching China National Knowledge Infrastructure(CNKI),WanFang Database,Chinese Science and Technology Journal Database(VIP),SinoMed,PubMed,the Cochrane Library,EMbase,and Web of Science,etc.Data were extracted independently by two researchers and the quality of the included studies was evaluated according to the Cochrane systematic evaluation manual.Meta-analysis was performed using RevMan 5.3 software.Results:Finally,17 RCT were included,involving 1 694 patients,including 849 patients in the experimental group and 845 patients in the control group.The results of meta-analysis showed that in the experimental group decrease of total cholesterol(MD=1.03,95%CI 0.55-1.51,P＜0.000 1),triacylglycerol(MD=0.41,95%CI 0.23-0.59,P＜0.000 1),low density lipoprotein cholesterol(MD=0.57,95%CI 0.29-0.85,P＜0.000 1)and hypersensitive C-reactive protein(MD=3.49,95%CI 2.07-4.90,P＜0.000 01)were better than those of the control group.The experimental group was also better than the control group in raising HDL cholesterol(MD=0.18,95%CI 0.08-0.28,P=0.000 5).The total effective rate of the experimental group was higher than that of the control group(RR=1.21,95%CI 1.16-1.27,P＜0.000 01).The adverse reactions were mainly gastrointestinal symptoms,and there were no serious adverse cardiac events.Conclusion:Existing evidence shows that Tongxinluo combined with statin is better than statin alone for the treatment of unstable angina pectoris dyslipidemia,with better safety.Due to the limited number of included studies,small sample size and low methodological quality,the results of this study need to be confirmed by high-quality clinical trials.
Keywords：unstable angina pectorisdyslipidemiaTongxinluostatinblood lipidsystem evaluation
Publication Date：2025-04-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 983-990 )