Effect of Yiqi Huotan Huayu Formula on Serum MMP-9,HDL-C,LDL-C,and Lp(a)in Patients with Severe Coronary Artery Stenosis

CUI Xilei; XU Huimei; LU Ruihua

doi:10.12102/j.issn.1672-1349.2025.06.020

Abstract：Objective: To observe the effect of Yiqi Hutan Huayu Decoction on serum matrix metalloproteinase-9 (MMP-9), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a) [Lp(a)] levels in patients with severe coronary artery stenosis. Methods: A total of 60 patients with severe coronary artery stenosis who were treated at the Department of Cardiology, Heilongjiang Academy of Traditional Chinese Medicine from January 2020 to January 2022 were selected. The patients were randomly divided into a control group and a study group, with 30 patients in each group. The control group received conventional Western medicine treatment, while the study group received Yiqi Hutan Huayu Decoction in addition to the treatment given to the control group. The clinical efficacy, TCM syndrome scores, coronary CT angiography (CTA) parameters, serum MMP-9, HDL-C, LDL-C, Lp(a) levels, incidence of adverse reactions, and occurrence rate of adverse cardiovascular events within one year were compared between the two groups. Results: The total effective rate in the study group (96.67%) was higher than that in the control group (73.33%), with a statistically significant difference (P < 0.05). After treatment, the scores for chest pain, chest tightness, palpitations, shortness of breath, dark complexion, fatigue, percentage of diameter stenosis (DS), percentage of area stenosis (AS), and serum MMP-9, LDL-C, and Lp(a) levels were lower than before treatment in both groups, while the minimum lumen area (MLA) and minimum lumen diameter (MLD) were higher than before treatment. Moreover, the study group showed better results than the control group, with statistically significant differences (P < 0.05). The incidence of adverse cardiovascular events within one year in the study group (3.33%) was lower than that in the control group (30.00%), with a statistically significant difference (P < 0.05). Conclusion: Yiqi Hutan Huayu Decoction can significantly alleviate TCM symptoms in patients with severe coronary artery stenosis, improve the degree of coronary artery stenosis, correct lipid abnormalities, reduce serum MMP-9 levels, and decrease the incidence of adverse cardiovascular events, without causing serious adverse reactions.