Prognostic Value of Serum LncRNA ZFAS1 and LncRNA TUG1 for Prognosis in Elderly Patients with Chronic Heart Failure
LIU Xiaolin
MA Wenhui
ZHANG Yujie
YU Huapeng
MA Shengting
Abstract：Objective:To observe the prognostic value of serum long non-coding RNA zinc finger NFX1 antisense RNA1(LncRNA ZFAS1)and long non-coding RNA taurine up-regulated gene 1(LncRNA TUG1)in elderly patients with chronic heart failure(CHF).Methods:Two hundred and seven elderly CHF patients were selected(CHF group),and 56 healthy subjects(control group)were selected.According to the prognosis of elderly CHF patients,they were divided into poor prognosis group(76 cases)and better prognosis group(131 cases).The levels of serum LncRNA ZFAS1 and LncRNA TUG1 were detected by quantitative reverse transcription polymerase chain reaction(qRT-PCR).The value of evaluating prognosis based on serum LncRNA ZFAS1 and LncRNA TUG1 levels analyzed by multivariate unconditional Logistic regression analysis and receiver operating characteristic(ROC)curve analysis,respectively.Results:The levels of serum LncRNA ZFAS1 and LncRNA TUG1 in the CHF group were higher than those in the control group(P＜0.001).The levels of serum LncRNA ZFAS1 and LncRNA TUG1 in the poor prognosis group were higher than those in the better prognosis group(P＜0.001).LncRNA ZFAS1(OR=1.232,95%CI 1.093-1.390)and LncRNA TUG1(OR=1.062,95%CI 1.024-1.102)were independent risk factors for poor prognosis in elderly patients with CHF(P＜0.05).ROC curve analysis showed that the area under ROC curve of serum LncRNA ZFAS1 and LncRNA TUG1 for poor prognosis in elderly patients with CHF were 0.784,0.777,and 0.863,respectively.Conclusion:Elevated levels of serum LncRNA ZFAS1 and LncRNA TUG1 in elderly patients with CHF were independent risk factors for poor prognosis.The combination of serum LncRNA ZFAS1 and LncRNA TUG1 showed a higher auxiliary prediction of poor prognosis in elderly patients with CHF,and might be an auxiliary predictor of poor prognosis in elderly patients with CHF.
Keywords：chronic heart failureelderlylong non-coding RNA zinc finger NFX1 antisense RNA1long non-coding RNA taurine up-regulated gene 1prognosis
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 836-840 )