Effect of Panax Notoginseng Saponins on Sirt1/Foxo1 Pathway in Rats with Chronic Heart Failure
YANG Hui
ZHONG Jianghua
MA Tianyi
AO Xue
SUN Dingjun
Abstract：Objective:To analyze the effect of panax notoginseng saponins on silencing information regulator 1(Sirt1)/forkead box 1(Foxo1)pathway in chronic heart failure rat model and its mechanism.Methods:A total of 50 SD rats aged from 6 to 8 weeks without specific pathogen(SPF)were selected,10 rats were used as control group,and the other 40 rats were set up chronic heart failure model.Thirty rats successfully modeled were divided into model group,low-dose group,and high-dose group,with 10 rats in each group.After successful modeling,the control group and model group were given normal saline by intragastric administration,the low-dose group was given normal saline+51 mg/kg notoginseng saponin by intragastric administration,and the high-dose group was given normal saline+105 mg/kg by notoginseng saponin intragastric administration,once a day,for 4 weeks.Cardiac function,heart failure index,myocardial fibrosis degree,inflammatory factor level,Sirt1/Foxo1 pathway protein expression were observed.Results:Compared with the control group,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),N-terminal pro-brain natriuretic peptide(NT-proBNP),myoglobin(Mb),cardiac troponin Ⅰ(cTnⅠ),creatine kinase isoenzyme(CK-MB),myocardial collagen volume fraction(CVF),the ratio of perivascular collagen area to vascular lumen area(PVCA/LA),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in model group,low-dose group,and high-dose group increased,while the expression of left ventricular short axis shortening rate(LVFS),left ventricular ejection fraction(LVEF),Sirt1,and Foxo1 decreased(P＜0.05).Compared with model group,the levels of LVEDD,LVESD,NT-proBNP,Mb,cTnⅠ,CK-MB,CVF,PVCA/LA,IL-6,and TNF-α in the low-dose group and high-dose group decreased,while the levels of LVFS,LVEF,Sirt1,and Foxo1 increased(P＜0.05).Compared with the low-dose group,the levels of LVEDD,LVESD,NT-proBNP,Mb,cTnⅠ,CK-MB,CVF,PVCA/LA,IL-6,and TNF-α in the high-dose group decreased,while the levels of LVFS,LVEF,Sirt1,and Foxo1 increased(P＜0.05).Conclusion:Panax notoginseng saponins can alleviate myocardial tissue injury and fibrosis in rats and improve their cardiac function,and its mechanism may be related to Sirt1/Foxo1 pathway.
Keywords：chronic heart failuremyocardial fibrosispanax notoginseng saponinssilencing information regulator 1/forkead box 1 pathway
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 684-689 )