Efficacy Analysis of Serum MCP-1,NLR,SFRP and Residual SYNTAX Score in Predicting the Risk of Adverse Events in Patients with Acute Myocardial Infarction after PCI
ZHAO Jianheng
NIU Hongxia
GUO Xumei
MAO Yueran
DAI Lili
Abstract：Objective: To analyze the efficiency of serum monocyte chemotactic protein-1 (MCP-1), neutrophil-to-lymphocyte ratio (NLR), secreted frizzled-related protein (SFRP), and residual SYNTAX score (rSS) in predicting the risk of major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods: A total of 160 AMI patients who underwent PCI at the emergency department of Beijing Electric Power Hospital between June 2021 and December 2022 were selected. These patients were divided into MACE group (18 cases) and non-MACE group (142 cases) based on whether MACE occurred within 3 months after surgery (including non-fatal myocardial infarction, unplanned revascularization, and hospitalization due to heart failure). Clinical data, preoperative and postoperative 1-day serum levels of MCP-1, NLR, SFRP, and rSS were compared between the two groups. Multivariate logistic regression analysis was used to identify risk factors for MACE. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of each indicator for MACE after PCI in AMI patients. Results: The proportion of diabetes and the proportion of lesions in the left anterior descending artery were higher in the MACE group than in the non-MACE group, with statistically significant differences (P < 0.05). There were statistically significant differences in serum MCP-1, NLR, SFRP levels, and rSS between the MACE group and non-MACE group before and after surgery (P < 0.05). Elevated serum MCP-1 (OR = 3.691) and NLR (OR = 2.751) levels, and low SFRP (OR = 0.355) and rSS (OR = 0.361) levels after 1 day of surgery were independent risk factors for MACE after PCI in AMI patients (P < 0.05). ROC analysis showed that serum MCP-1, NLR, SFRP levels, and rSS after 1 day of surgery could predict the occurrence of MACE within 3 months after PCI in AMI patients (P < 0.05). Conclusion: Serum MCP-1, NLR, SFRP levels, and rSS measured 1 day after PCI in AMI patients can predict the occurrence of MACE within 3 months after PCI.
Keywords：acute myocardial infarctionpercutaneous coronary interventionmajor adverse cardiovascular events
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 576-580 )