The Effectiveness of Soothing Liver,Regulating Qi,and Activating Blood Method for Treating Coronary Heart Disease Combined with Depression:a Network Meta-analysis
GAO Lu
KONG Dezhao
CAO Yubo
WANG Sijia
ZHANG Zhe
Abstract：Objective:To compare the efficacy and safety of different prescriptions for regulating Qi and promoting blood circulation for treating coronary heart disease complicated with depression.Methods:The databases of CNKI,WanFang Data,VIP,SinoMed,PubMed,EMbase,The Cochrane Library,and Web of Science were retrieved to collect randomized controlled trials(RCTs)of the treatment of coronary heart disease complicated with depression with different liver-soothing,Qi-regulating and blood-activating prescriptions,as well as RCTs of antidepressants for treating coronary heart disease complicated with depression.The search time was from database establishment to May 20,2023.After screening the literature,extracting the data,and evaluating the risk of bias for the included studies,the mesh Meta analysis was performed using ADDIS 1.16.6 and Stata/SE 15.0 software,and the GRADE grading and minimum background framework with high confidence.Results:A total of 16 RCTs were included,including 2 TCM prescriptions and 4 selective serotonin reuptake inhibitors(SSRIs).Network Meta analysis and minimum background framework results showed that:for redution of the score of Hamilton Depression Scale(HAMD),coronary heart disease treatment+paroxetine+Xuefu Zhuyu Decoction might be the best therapy,followed by coronary heart disease treatment+paroxetine,coronary heart disease treatment+fluoxetine,coronary heart disease treatment+sertraline,coronary heart disease treatment+citalopram.In terms of reducing C-reactive protein(CRP)levels,the combination of coronary heart disease treatment and citalopram might be the most effective therapy,followed by coronary heart disease treatment+paroxetine,coronary heart disease treatment+Shugan Jieyu Decoction.Conclusion:Current evidence shows that the treatment of coronary heart disease+paroxetine+Xuefu Zhuyu Decoction could reduce the HAMD scale score.Coronary heart disease treatment+citalopram could reduce the CRP value most effectively.The individualized treatment based on specific situations and drug characteristics is necessary,but due to limitations in the quantity and quality of studies,this conclusion requires further observation with high-quality research.
Keywords：coronary heart diseasesoothing liverregulating Qiand activating bloodtraditional Chinese medicinedepressionBayesian analysis methodsnetwork meta-analysisminimum background frameGRADE classification
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 503-512 )