The Key Genes of Essential Hypertension and Prediction of Potential Targeted Chinese Medicines Based on Bioinformatics
LI Nachuan
ZHANG Hongxiao
ZHANG Meng
ZHAO Fanying
CHEN Ziqi
WANG Xiangzhao
LIU Ziwang
Abstract：Objective:To analyze the key genes of essential hypertension(EHT)based on bioinformatics and to predict the potential targeted Chinese medicines and traditional Chinese medicine(TCM)active ingredients.Methods:The GSE75940 dataset was selected from the GEO database,and after screening for EHT differentially expressed genes(DEGs),enrichment analyses were performed to construct protein-interaction networks and screen key genes.The cBioPortal database was utilized for mutation and survival analysis of key genes.Potential targeted Chinese medicines and TCM active ingredients were screened in Coremine Medical and CTD databases.Results:A total of 1 832 DEGs were screened and the enrichment results were mainly related to synapses,neuropeptides,neuroactivity,G protein-coupled receptors,and neutrophil migration.The seven key genes were epidermal growth factor receptor(EGFR),CXC chemokine receptor 4(CXCR4),interleukin 17A(IL17A),integrin alpha M(ITGAM),Bruton tyrosine kinase(BTK),pro-opiomelanocortin(POMC),and CD86.The predicted potential Chinese medicines could be categorized into three main groups:clearing heat and detoxifying and cooling blood,dispelling dampness and phlegm,nourish the liver and kidneys,which was consistent with the pathogenesis of EHT fire,phlegm,and weakness.The active ingredients of TCM include resveratrol,genistein,quercetin,curcumin,capsaicin,rotenone,paclitaxel,etc.,which were related to the occurrence and development of EHT.Conclusion:In this study,7 key genes of EHT were screened and predicted to target TCM and effective active ingredients,which can provide new biomarkers for subsequent studies and promote the prevention and treatment of EHT in Chinese medicine.
Keywords：essential hypertensionbioinformaticskey genesactive ingredient of traditional Chinese medicine
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 487-495 )