Tei Index and Free Triiodothyronine on Predicting Long-term Prognosis in Patients with Dilated Cardiomyopathy
CHANG Xuewei
SHEN Yu
ZHENG Weifeng
GU Yunfei
WEI Jinghan
WEI Yidong
Abstract：Objective: To explore the predictive value of Tei index combined with free triiodothyronine (FT3) for the long-term prognosis of patients with dilated cardiomyopathy (DCM). Methods: A total of 312 DCM patients hospitalized at Luoyang Central Hospital, Zhengzhou University from May 2016 to October 2018 were selected. After a follow-up period of (40.46±1.89) months, 93 cases (29.81%) experienced major adverse cardiovascular events (MACE). Patients were divided into MACE group (n=93) and non-MACE group (n=219). Cox regression analysis was used to identify factors influencing MACE during follow-up. Receiver operating characteristic (ROC) curves were applied to evaluate the predictive value of Tei index and FT3 for MACE during follow-up. Results: The NYHA heart function classification, left ventricular end-diastolic diameter (LVEDD), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and Tei index were higher in the MACE group compared to the non-MACE group (P<0.05), while the application rate of renin-angiotensin-aldosterone system (RAAS) inhibitors and FT3 levels were lower in the MACE group (P<0.05). The higher the NYHA heart function classification, the higher the Tei index and the lower the FT3 level in DCM patients. Multivariate Cox regression analysis showed that Tei index [HR=1.039, 95%CI (1.026, 1.051)] and FT3 [HR=0.464, 95%CI (0.372, 0.578)] were independent risk factors for MACE during follow-up. The area under the curve (AUC) for predicting MACE was 0.700 for Tei index and 0.750 for FT3. The combination of Tei index and FT3 had better predictive value (AUC=0.809), with sensitivity of 75.3% and specificity of 73.1%. Patients with Tei index >0.66 and FT3 <3.39 pmol/L had a higher incidence of MACE (Log-Rank χ²=80.454, P<0.05). Conclusion: The combination of Tei index and FT3 has better predictive value for the prognosis of DCM. Patients with high Tei index and low FT3 have worse prognosis.
Keywords：dilated cardiomyopathyheart failuretriiodothyronineejection fractionmajor adverse cardiac events
Publication Date：2025-02-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 407-412 )