The Prognostic Predictive Value of Hemoglobin and Serum Protein Levels in Elderly Patients with Unstable Angina Pectoris with Normal Left Ventricular Function after PCI
LI Hua
LIU Peilin
DONG Dandan
WU Hao
Abstract：Objective: To explore the predictive value of hemoglobin (Hb) and serum albumin (ALB) for long-term prognosis in elderly patients with normal left ventricular function and unstable angina pectoris (UA) undergoing percutaneous coronary intervention (PCI). Methods: A total of 106 patients with normal left ventricular function diagnosed with UA and treated with PCI at Beijing Tongren Hospital, Capital Medical University, from December 2019 to May 2022 were selected. According to whether major adverse cardiovascular events (MACE) occurred during follow-up, the patients were divided into the no-MACE group (58 cases) and the MACE group (48 cases). Clinical data between the two groups were compared. Multivariate logistic regression analysis was used to identify factors associated with MACE occurrence. Smooth curve fitting was applied to analyze the relationship between serum Hb, ALB, and MACE, and a predictive model was constructed. Results: Compared with the no-MACE group, the MACE group had higher rates of hypertension history and previous myocardial infarction (P < 0.05); serum creatine kinase isoenzyme (CK-MB), uric acid, high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and troponin I (cTnI) levels were elevated (P < 0.05 or P < 0.01), while serum Hb, ALB levels, and left ventricular ejection fraction (LVEF) were decreased (P < 0.01). Previous myocardial infarction, elevated serum hs-CRP, elevated serum NT-proBNP, reduced serum Hb, reduced serum ALB, and reduced LVEF were independent risk factors for MACE. Hb and ALB showed a linear negative correlation with the occurrence of MACE. When Hb ≥ 117.8 g/L, each increase of 10 g/L in Hb reduced the risk of MACE by 17% (P < 0.05). When ALB ≥ 34.70 g/L, each increase of 1 g/L in ALB reduced the risk of MACE by 14% (P < 0.05). The constructed nomogram model demonstrated good discrimination, accuracy, and clinical validity. Conclusion: Low serum Hb and ALB levels are independent risk factors for poor prognosis in elderly patients with normal left ventricular function and UA undergoing PCI, and have good predictive value for prognosis.
Keywords：unstable angina pectorispercutaneous coronary interventionhemoglobinalbuminleft ventricular functionoutcome
Publication Date：2025-02-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 401-406 )