The Mechanism of Erxian Decoction for the Treatment of Postmenopausal Coronary Heart Disease Complicated with Osteoporosis Based on Network Pharmacology and Molecular Docking Technology
YANG Ying
LIU Haixia
ZHANG Zhiguo
CHEN Yanjing
Abstract：Objective:To analyze the mechanism of Erxian decoction(EXD)for the treatment of postmenopausal coronary heart disease complicated with osteoporosis based on network pharmacology and molecular docking technology.Methods:The target proteins of EXD were obtained from the pharmacologic database and analysis platform of traditional Chinese medicine system,and the related proteins of postmenopausal osteoporosis and postmenopausal coronary heart disease were obtained from GeneCards and OMMI database.Cytoscape software,STRING database,and DAVID database were used to screen the key target proteins,targets and pathways of EXD for the treatment of postmenopausal coronary heart disease complicated with osteoporosis.Finally,the close relationship between the key target and the target protein was verified by molecular docking.Results:The network pharmacological study showed that the core components of EXD for the treatment of postmenopausal coronary heart disease and osteoporosis were quercetin,kaempferol,beta-sitosterol,Stigmasterol,Anhydroicaritin Luteolin,and the key targets were protein kinase B(AKT1),tumor necrosis factor(TNF),interleukin(IL)-6,IL-1β,prostaglandin G/H synthase 2(PTGS2),JUN,matrix metalloproteinase-9(MMP9),Caspase 3(CASP3),epidermal growth factor(EGF),and vascular endothelial growth factor A(VEGFA).Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis showed that EXD played some role in the treatment of postmenopausal coronary heart disease and osteoporosis through phosphatidylinositol 3-kinase(PI3K)-AKT pathway,MAPK pathway,and TNF signaling pathway.The results of molecular docking showed that the binding of key targets and key compounds was stable.Conclusion:The results of network pharmacology and molecular docking showed that EXD showed a multi-target and multi-pathway synergistic effect for the treatment of postmenopausal osteoporosis and coronary heart disease.EXD could play an anti-postmenopausal coronary heart disease complicated with osteoporosis through various pathways such as PI3K-AKT pathway,MAPK pathway and TNF signaling pathway.
Keywords：postmenopausal coronary heart diseasepostmenopausal osteoporosisErxian decoctionnetwork pharmacologymolecular docking
Publication Date：2025-02-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 349-358 )