Prediction of In-stent Restenosis by Serum Calcineurin in Patients with Acute Myocardial Infarction after PCI

ZHAO Yong; LIU Ming

doi:10.12102/j.issn.1672-1349.2025.01.016

Abstract：Objective: To explore the predictive value of serum calmodulin-dependent protein phosphatase (CaN) for in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods: A total of 130 AMI patients treated at the First People's Hospital of Jining City from September 2020 to March 2022 were selected as the study subjects. All patients underwent direct PCI and were followed up for 1 year after discharge. According to the occurrence of ISR during follow-up, the patients were divided into ISR group and non-ISR group. The general data, serum CaN levels, and other laboratory indicators at discharge were compared between the two groups. Multivariate logistic regression analysis was used to identify the influencing factors of ISR after PCI in AMI patients. Receiver operating characteristic (ROC) curves were drawn to analyze the predictive value of serum CaN levels at discharge for ISR after PCI in AMI patients. Results: Among the 130 AMI patients who underwent PCI, 25 cases developed ISR within 1 year of follow-up, with an incidence rate of 19.23%. The body mass index was higher in the ISR group than in the non-ISR group, while the main stent diameter was smaller in the ISR group. At discharge, serum low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), and CaN levels were higher in the ISR group than in the non-ISR group (P < 0.05). Multivariate logistic regression analysis showed that the main stent diameter, serum CRP, and CaN levels at discharge were independent risk factors for ISR after PCI in AMI patients (P < 0.05). The ROC curve showed that the area under the curve for serum CaN levels at discharge in predicting ISR after PCI in AMI patients was 0.709, indicating a certain predictive value. Conclusion: Elevated serum CaN levels are an independent risk factor for ISR after PCI in AMI patients and can be used for early prediction of the risk of ISR after PCI in AMI patients.