Relationship between MAp44,S-100B Protein and Severity of Acute Myocardial Infarction

YUAN Dejun; WANG Ling; FU Jia

doi:10.12102/j.issn.1672-1349.2025.01.014

Abstract：Objective: To analyze the correlation between mannose-binding lectin-associated protein 44 (MASP44), S-100 calcium-binding protein B (S-100B) and the severity of acute myocardial infarction. Methods: A total of 60 patients with acute myocardial infarction admitted to our hospital from February 2022 to January 2023 were selected as the study group, and 40 healthy volunteers who underwent physical examination at our hospital were selected as the control group. Both groups underwent detection of MASP44 and S-100B protein levels. The severity of the disease was assessed using the Killip classification of cardiac function. The correlation between MASP44, S-100B and the severity of the disease, as well as the influencing factors of the severity of the disease, were analyzed. Results: Compared with the control group, the MASP44 protein level was lower, and the S-100B protein level was higher in the study group (P < 0.05). MASP44 protein was negatively correlated with the Killip classification of cardiac function, while S-100B protein was positively correlated with the Killip classification (P < 0.05). Univariate analysis showed that the severity of acute myocardial infarction was not related to gender, age, body mass index (BMI), smoking, or drinking (P > 0.05). The severity of acute myocardial infarction was related to infarct size, cardiac troponin I (cTnI), brain natriuretic peptide (BNP), number of lesions, MASP44 protein, and S-100B protein. Patients with class IV acute myocardial infarction had a higher proportion of large infarcts and two or three-vessel lesions, higher levels of cTnI, BNP, and S-100B protein, and lower MASP44 protein levels compared to patients with class I, II, or III acute myocardial infarction (P < 0.05). Multivariate logistic regression analysis showed that infarct size, cTnI, BNP, number of lesions, MASP44 protein, and S-100B protein were major factors affecting the severity of acute myocardial infarction (P < 0.05). Conclusion: Patients with acute myocardial infarction have lower MASP44 protein levels and higher S-100B protein levels. Both MASP44 and S-100B proteins are related to the severity of acute myocardial infarction.