Relationship between H131R Polymorphism of FCGR2A Gene and the Risk of Kawasaki Disease:a Meta-analysis

LIU Yanling; LI Liang; LI Qin

doi:10.12102/j.issn.1672-1349.2025.01.005

Abstract：Objective:To analyze the relationship between the risk of Kawasaki disease(KD)between H131R polymorphism of immunoglobulin G(IgG)receptor FCGR2A gene through meta-analysis.Methods:PubMed,EMbase,Web of Science,Wiley Library,China National Knowledge Infrastructure(CNKI),Wanfang and Chinese Science and Technology Journal Database(VIP)databases were searched for articles related the correlation between H131R polymorphism of FCGR2A gene and the risk of Kawasaki disease.The data were updated to April 1,2023.Newcastle-ottawa Scale(NOS)was used to evaluate literature quality.R 4.2.2 software was used for Meta-analysis.Results:A total of 9 literatures were included in this study,including 4 366 patients in the KD group and 20 882 patients in the control group,all of which were high-quality literatures.The Meta analysis results showed that(taking heterozygote model HR vs RR as an example):the H131R polymorphism of FCGR2A gene correlated with the incidence of Kawasaki disease(OR=1.27,95％CI 1.03-1.58,P=0.03).Subgroup analysis showed that H131R polymorphism associated with the incidence of Kawasaki disease in Caucasian population(OR=1.38,95％CI 1.08-1.76).There was no association between H131R polymorphism and the incidence of Kawasaki disease in Asians(OR=1.21,95％CI 0.86-1.71).There was a correlation between H131R polymorphism of FCGR2A gene and KD combined CAL(OR=1.44,95％CI 1.15-1.81,P＜0.01).Conclusion:The polymorphism of FCGR2A gene H131R gene relates the risk of Kawasaki disease,and its H allele increases the risk of Kawasaki disease.However,considering the limited number of included literatures,more relevant studies are needed for further verification.