Mechanism of Traditional Chinese Medicine Compound for Benefiting Qi and Activating Blood Circulation for Treating Chronic Heart Failure Based on Metabolomics Technique
ZHANG Xiao
WANG Dongling
LIU Jiangang
Abstract：Objective:To explore the biomarkers and metabolic pathways involved in the treatment of chronic heart failure by traditional Chinese medicine ( TCM) compound for benefiting Qi and activating blood circulation based on metabolomics technique,providing scientific basis for the efficacy evaluation,adverse reaction evaluation and clinical application of pharmacokinetics in the treatment of chronic heart failure with TCM.Methods:The relevant literatures of the treatment of heart failure by compound for benefiting Qi and activating blood circulation were retrieved from China National Knowledge Infrastructure ( CNKI ) database,Wanfang,VIP,China Biomedical Literature Service System(SinoMed),PubMed,EMbase,Web of Science core database,and the Cochrane Library.The time limit of the search was from the establishment of the library to May 2023. The relevant literature obtained was screened and the differential metabolites included in the study were extracted and summarised,the metabolites were molecularly annotated using Human Metabolome Database(HMDB),PubChem and Kyoto Encyclopedia of Genes and Genomes(KEGG).The metabolites were analysed using the Metabo Analyst 5.0 web software for KEGG enrichment analysis of metabolite pathways. Results:A total of 11 literatures were included,involving Qiliqiangxin Capsules,Qishenyiqi Drops Pills,Xin Yang Tablets,Xin Fukang Oral Liquid,Jia Sheng Formula,Yi Xin Shu Capsules,and Qiweiqiangxin No.1.A total of 115 differential metabolites were screened out with VIP>1 and P<0.05.Pathway enrichment analysis was performed.There were 14 metabolic pathways with P values less than 0.05,which could be used as a beneficial Chinese medicinal herb for the treatment of heart failure.Conclusion:The TCM compound with benefiting Qi and activating blood circulation can significantly improve myocardial metabolite disorders in chronic heart failure patients or rats,and its mechanism of action may be related to the regulation of amino acid metabolism(e.g.,alanine,phenylalanine),glucose metabolism(e.g.,lactic acid ),lipid metabolism ( e. G.,lysophosphatidylcholine,lysophosphatidylinositol ),and the improvement of cardioenergetic metabolism.
Keywords：heart failuremetabolomicsbenefiting Qi and activating blood circulationtraditional Chinese medicine compoundbiomarkersmechanism
Publication Date：2024-12-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 4235-4243 )